Modulation of inflammatory mediators inthe trigeminal ganglion by botulinumneurotoxin type A: an organ culture study

We report that CGRP, iNOS, IL-1β, SNAP-25 and SV2-A were observed in fresh TG with a differentialdistribution. Interestingly, NaCl organ culture of the TG resulted in enhanced expression of CGRP and SNAP-25 inneurons and iNOS in SGCs. Co-incubation with U0126 or BoNT-A retained the increased expression of SNAP-25,while it decreased the IL-1βimmunoreactivity in neurons. The iNOS expression in SGCs returned to levels observedin fresh specimens. Moreover, we observed no alteration SV2-A expression in SGCs. Thus, the overall picture is thatboth U0126 and BoNT-A have the ability to modify the expression of certain molecules in the TG.
Автор:  Jacob Edvinsson, Karin Warfvinge and Lars Edvinsson
Год публикации:  2015
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