The 7th Triennial Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins - Toxins 2011

The 7th Triennial Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins - Toxins 2011 will be held in Santa Fe, New Mexico, US,from October 2-5, 2011. The meeting organizers have put together a program consisting of internationally known basic and clinical scientists who will speak on the latest understandings of the basic biology of the neurotoxins and the science underlying their clinical applications. The Toxins 2011 meeting will be immediately followed by the 48th Annual Interagency Botulism Research Coordinating Committee – IBRCC Meeting scheduled to be held in Santa Fe, New Mexico, US from October 6 – 7, 2011 which will focus on clinical botulism, epidemiology, and therapeutic interventions for botulism including vaccines, antitoxins and small molecule therapeutics. The organizers have developed programs for the two meetings with minimal overlap and encourage attendees to participate in both meetings.

 Scientific Program

Sunday, October 2, 2011

    12:00 PM  -  7:30 PM     
    Registration – Santa Fe Convention Center
        
    6:00 PM  -  9:00 PM     
    Opening Reception  (at Convention Center)
        

Monday, October 3, 2011

    7:00 AM  -  5:00 PM     
    Registration – Santa Fe Convention Center
        
    8:00 AM  -  5:00 PM     
    Exhibits Open
        
    8:00 AM  -  11:50 AM     
    Session I: Structure & function of botulinum neurotoxin: sequence diversity,binding & transcytosis
    Chairs: Lance Simpson and Eric Johnson
        
    8:00 AM      
    Chairperson's opening remarks and keynote speaker introduction
        
    8:10 AM      
    Keynote presentation - Life history of a botulinum neurotoxin molecule
    Speaker - Lance Simpson (Confirmed)
        
    8:50 AM      
    Genetic diversity between and within botulinum neurotoxin serotypes
    Speaker - Karen Hill (Confirmed)
        
    9:15 AM      
    Impact of sequence variability in botulinum neurotoxin subtypes
    Speaker- Eric Johnson (Confirmed)
        
    9:40 AM      
    Binding receptors of bolulinum neurotoxins
    Speaker - Andreas Rummel (Confirmed)
        
    10:05 AM      
    Networking Coffee Break
        
    10:35 AM      
    Receptor binding site of bolulinum neurotoxin types C and D
    Speaker - Shunji Kozaki (Confirmed)
        
    11:00 AM      
    How botulinum neurotoxins bind and enter neurons
    Speaker - Ed Chapman (Confirmed)
        
    11:25 AM      
    Function of HCN domain
    Speaker - Cesare Montecucco (Confirmed)
        
    11:50 AM  -  12:20 PM     
    Lunch Break
        
    1:20 PM  -  5:00 PM     
    Session II: Botulinum toxin in pain disorders
    Chairs: Steven Silberstein and Lars Arendt-Nielsen
        
    1:20 PM      
    Chairperson's opening remarks and keynote introduction
        
    1:30 PM      
    Keynote presentation: Neurobiological basis for the use of botulinum toxin in pain therapy
    Speaker - Siegfried Mense (Invited)
        
    2:10 PM      
    The effect of botulinum neurotoxin on pain transduction and sensitization
    Speaker - Lars Arendt-Nielsen (Confirmed)
        
    2:35 PM      
    Botulinum toxin for migraine
    Speaker - Steven Silberstein (Confirmed)
        
    3:00 PM      
    Networking Coffee Break
        
    3:30 PM      
    Botulinum toxin for rare pain syndromes
    Speaker Invited
        
    3:55 PM      
    Re-targeting of bolulinum neurotoxins
    Speaker - Keith Foster (Confirmed)
        
    4:20 PM      
    Selected short/poster presentations
    Three 10 minute talks
        
    5:00 PM      
    Adjournment
        

Tuesday, October 4, 2011

    7:30 AM  -  5:00 PM     
    Registration – Santa Fe Convention Center
        
    8:00 AM  -  5:00 PM     
    Exhibits Open
        
    8:00 AM  -  11:50 AM     
    Session III Structure & function of botulinum neurotoxin: binding, translocation&substrate cleavage
    Chairs: Mauricio Montal and Cesare Montecucco
        
    8:00 AM      
    Chairperson's opening remarks and keynote introduction
        
    8:10 AM      
    Keynote presentation: How light chain is translocated into the cytosol
    Speaker - Mauricio Montal (Confirmed)
        
    8:50 AM      
    Function of the translocation domain belt
    Speaker - Daniel Gillet (Confirmed)
        
    9:15 AM      
    Mode of substrate binding and cleavage
    Speaker - Subramanyam Swaminathan (Confirmed)
        
    9:40 AM      
    Networking Coffee Break
        
    10:10 AM      
    Molecular mechanism of Ca2+ triggered vesicle fusion & structural basis of BoNT-substrate cleavage
    Speaker - Axel Brunger (Confirmed)
        
    10:35 AM      
    Cytosolic modification and degradation of light chain
    Speaker - George Oyler (Confirmed)
        
    11:00 AM      
    Re-engineered LC's for non-substrate SNARE's
    Speaker - Joe Barbieri (Confirmed)
        
    11:25 AM      
    Selected short/poster presentations
    Three 10 minute talks
        
    11:50 AM  -  1:20 PM     
    Lunch Break
        
    1:20 PM  -  5:00 PM     
    Session IV: Clinical and systemic responses to botulinum neurotoxins
    Chair: Dirk Dressler
        
    1:20 PM      
    Chairperson's opening remarks and keynote introduction
        
    1:30 PM      
    Keynote presentation: Comparative trials of botulinum toxin drugs
    Speaker - Cindy Comella (Confirmed)
        
    2:10 PM      
    Ultrasound-guided botulinum neurotoxin placement
    Speaker Invited
        
    2:35 PM      
    Mechanisms of antibody neutralization of botulinum neurotoxins
    Speaker - James Marks (Confirmed)
        
    3:00 PM      
    Networking Coffee Break
        
    3:30 PM      
    Antigenicity of botulinum toxin drugs
    Speaker - Dirk Dressler (Confirmed)
        
    3:55 PM      
    Measuring botulinum toxin antibodies
    Speaker - Hans Bigalke (Confirmed)
        
    4:20 PM      
    Selected short/poster presentations
    Three 10 minute talks
        
    5:00 PM      
    Adjournment
        
    6:00 PM  -  10:00 PM     
    Gala Banquet
    Transportation departs from hotels at 6:00
        

Wednesday, October 5, 2011

    7:30 AM  -  5:00 PM     
    Registration – Santa Fe Convention Center
        
    8:00 AM  -  5:00 PM     
    Exhibits Open
        
    8:00 AM  -  11:50 AM     
    Session V: CNS and autonomic effects of botulinum and tetanus neurotoxins
    Chairs: Giampietro Schiavo and Markus Naumann
        
    8:00 AM      
    Chairperson's opening remarks and keynote speaker introduction
        
    8:10 AM      
    Keynote presentation: Central effects of BoNT-Evidence in human and animal models
    Speaker - Matteo Caleo (Confirmed)
        
    8:50 AM      
    Retrograde transport and transytosis of proteins in the CNS
    Speaker - Tony Yaksh (Confirmed)
        
    9:15 AM      
    Peripheral cholinergic specificity of BoNTs
    Speaker - Jordi Molgo (Confirmed)
        
    9:40 AM      
    Networking Coffee Break
        
    10:10 AM      
    Similarities and differences between botulinum and tetanus neurotoxins
    Speaker - Giampietro Schiavo (Confirmed)
        
    10:35 AM      
    Mechanism of action of botulinum neurotoxin in hyperhydrosis
    Speaker - Markus Naumann (Confirmed)
        
    11:00 AM      
    Clinical use of botulinum neurotoxin for overactive bladder conditions
    Speaker - Roger Dmochowski (Confirmed)
        
    11:25 AM      
    Selected short/poster presentations
    Three 10 minute talks
        
    11:50 AM  -  1:20 PM     
    Lunch Break
        
    1:20 PM  -  5:30 PM     
    Session VI: Regulatory aspects of botulinum neurotoxin drugs
    Chair: Mark Hallet
        
    1:20 PM      
    Chairperson's opening remarks
        
    1:30 PM      
    Dose equivalence and potential systemic toxicity of botulimun neurotoxins
    Speaker - Christina Sampaio (Invited)
        
    1:55 PM      
    Counterfeit botulinum neurotoxin drugs
    Speaker - Andy Pickett (Invited)
        
    2:20 PM      
    Non-A/Non-B botulinum toxin for therapeutic use
    Speaker Invited
        
    2:45 PM      
    Reducing animal consumption for the production of botulinum neurotoxin drugs
    Speaker Invited
        
    3:10 PM      
    Networking Coffee Break
        
    3:40 PM  -  5:30 PM     
    The registration process for botulinum neurotoxin drugs: Chairs introduction
        
    3:45 PM      
    The clinicians prespective
    Speaker - Dirk Dressler (Confirmed)
        
    4:00 PM      
    The perspective of developing countries
    Speaker - Raymond Rosales (Confirmed)
        
    4:15 PM      
    The industry prespective
    Speaker Invited
        
    4:30 PM      
    The perspective of the regulatory authorities
    Speaker - Russell Katz (Invited)
        
    4:45 PM      
    Round Table Discussion: The registration process for botulinum neurotoxin drugs
    Chairperson: Mark Hallet (Confirmed): Panelists - Dressler, Rosales, Katz, Brin, Pickett
        
    5:30 PM      
    Adjournment
        
    7:00 PM  -  10:00 PM     
    Closing reception Toxins 2011 and Welcoming reception IBRCC